Human PI3K Mutations: Immunodeficiency and Malignancy
نویسندگان
چکیده
منابع مشابه
IRF8 mutations and human dendritic-cell immunodeficiency.
BACKGROUND The genetic analysis of human primary immunodeficiencies has defined the contribution of specific cell populations and molecular pathways in the host defense against infection. Disseminated infection caused by bacille Calmette-Guérin (BCG) vaccines is an early manifestation of primary immunodeficiencies, such as severe combined immunodeficiency. In many affected persons, the cause of...
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The human immunodeficiency virus (HIV) is lentivirus (subgroup of retrovirus) which causes HIV infection and it acquired immunodeficiency syndrome (AIDS). HIV infection leads to low levels of CD4+T cells through number of mechanisms [1]. Our purpose is to review educative HIV prevention and control as Millennium Development Goal (MDG) and WHO's operational goal. In 2000, when ...
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Human immunodeficiency virus (HIV) infection has been associated with cardiac disease, including anatomical or functional disturbance to the heart. Cardiomyopathy (CMP) is one of these disturbances that have been associated with high rates of morbidity and mortality. In this review article, several aspects of potential relationships between HIV infection and cardiomyopathy development have been...
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The class I phosphoinositide 3-kinases (PI3Ks) are especially involved in the cell response to extracellular signals and convert phosphatidylinositol-(4,5)-bisphosphate (PIP2) into phosphatidylinositol-(3,4,5)-triphosphate (PIP3), an important intracellular " second messenger " , activating many different intracellular enzymes, including Akt also known as protein-kinase B. Class IA PI3Ks are he...
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ژورنال
عنوان ژورنال: Blood
سال: 2020
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2020-133027